ODCs

Click node...

2 OMIM references -
2 associated genes
13 signs/symptoms

PROTEIN INTERACTIONS: 2

1 associated gene
No signs/symptoms info

Peripheral resistance to thyroid hormones

Severe combined immunodeficiency due to DNA-PKcs deficiency

THRA	(UniProt - OMIM)		PRKDC	(UniProt - OMIM)
THRB	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	THRA THRB	(0.68) (0.68)	PRKDC PRKDC

Citations in the biomedical literature:

Peripheral resistance to thyroid hormones		Severe combined immunodeficiency due to DNA-PKcs deficiency
	Synonym(s): (no synonyms)		Synonym(s): - SCID due to DNA-PKcs deficiency

	Classification (Orphanet): - Rare endocrine disease - Rare genetic disease		Classification (Orphanet): - Rare genetic disease - Rare immune disease

	Classification (ICD10): - Endocrine, nutritional and metabolic diseases -		Classification (ICD10): - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -

	Epidemiological data: (no data available)		Epidemiological data: (no data available)

	External references: 2 OMIM references - No MeSH references		External references: No OMIM references No MeSH references

Peripheral resistance to thyroid hormones
	Very frequent - Absent / hypotonic / flaccid abdominal wall muscles - Autosomal dominant inheritance - Coarse face - Constipation - Face / facial anomalies - Failure to thrive / difficulties for feeding in infancy / growth delay - Hepatitis / icterus / cholestasis - Hypothyroidy - Hypotonia - Large fontanelle / delayed fontanelle closure - Macroglossia / tongue protrusion / proeminent / hypertrophic - Sleep and vigilance disorders - Umbilical hernia
Severe combined immunodeficiency due to DNA-PKcs deficiency
(no data available)